How does glycation affect the brain?
Glycation alters the biological activity of proteins and their degradation processes.
Protein cross-linking by AGE results in the formation of detergent-insoluble and protease-resistant aggregates.
Such aggregates may interfere with both axonal transport and intracellular protein traffic in neurons..
How does glycation affect the vascular system?
AGEs accumulate in various organs of the body including the heart and large blood vessels, leading to accelerated plaque formation as well as increased cardiac fibrosis with consequent effects on cardiac dysfunction.
How does glycation affect the skin?
The human body does not recognize AGEs as normal, and will produce antibodies that cause inflammation in the skin. … Effects of the glycation process at the cellular level of the skin’s structure may result in wrinkling, loss of elasticity, stiffness, accelerated aging and compromised barrier function.
Can you reverse glycation damage?
Several antiaging skin care products claim to treat glycation, but – unfortunately – glycation is not a reversible reaction. It must be prevented in the first place.