Can Statins Cause Low Creatinine?

What is the first sign of kidney problems?

Signs and symptoms of acute kidney failure may include: Decreased urine output, although occasionally urine output remains normal.

Fluid retention, causing swelling in your legs, ankles or feet.

Shortness of breath..

Do statins help kidney function?

Recent systematic reviews and meta-analyses have indicated that statins do not reduce risk of kidney failure events in adults not receiving dialysis, where kidney failure events are defined as 25–50% decrease in eGFR, doubling of serum creatinine level, or advancement to ESRD stage during follow-up period; however, …

What is a bad creatinine level?

What are considered high creatinine levels? A person with only one kidney may have a normal level of about 1.8 or 1.9. Creatinine levels that reach 2.0 or more in babies and 5.0 or more in adults may indicate severe kidney impairment.

What is normal creatinine level?

The normal range for creatinine in the blood may be 0.84 to 1.21 milligrams per deciliter (74.3 to 107 micromoles per liter), although this can vary from lab to lab, between men and women, and by age.

Can you stop taking statins Once you start?

Therefore, most people who begin taking a statin medication will likely take it for the rest of their lives. If you’ve been taking statins and would like to stop, you’ll need to do so with your doctor’s guidance. This is because it can be dangerous to stop taking statins.

Which statin has the least amount of side effects?

In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications.

Which statin is safest for kidneys?

Although effect estimates and rankings of individual treatments were variable across the analyses, in general atorvastatin 40–80 mg, fluvastatin 20 mg/ezetimibe 10 mg, pravastatin 10–20 mg, simvastatin 10–40 mg, and fluvastatin 20 mg were the most effective treatments with regard to eGFR decline.

Which statin is safest in renal failure?

This includes moderate-intensity statins such as daily atorvastatin 20 mg, rosuvastatin 10 mg, simvastatin 40 mg, pravastatin 40 mg, fluvastatin 80 mg, or pitavastatin 2 mg. Fibrates should be avoided in combination with statins in patients with CKD, and ezetimibe monotherapy is not recommended.

Can Atorvastatin increase creatinine levels?

Renal function was examined in this study using Cockcroft-Gault derived creatinine clearance (CrCl) values. The mean CrCl at entry was 77 ml/min. Patients on atorvastatin showed a 12% rise in CrCl, patients on other statins a 4.9% rise in CrCl, and statin free patients a 5.2% fall in CrCl over 36 months of follow up.

Is low creatinine serious?

Creatinine levels vary from person to person depending on factors such as body size, age, or gender, so there is no standard or ‘normal’ level. Low creatinine levels could indicate a problem with the muscles or liver but may be due to something less serious, such as reduced muscle mass in older adults, or pregnancy.

Do creatinine levels change daily?

Creatinine levels can change rapidly, even throughout the day, which is why healthcare providers monitor them for an extended period of time. One blood test that returns high creatinine in blood could be a fluke. However, several tests in a row that show elevated levels could indicate chronic kidney disease.

Is atorvastatin hard on kidneys?

Patients taking powerful cholesterol-lowering drugs may be putting their kidneys at risk, according to the results of a landmark Canadian study. The researchers focused on “high-potency” statins – Crestor, Lipitor and Zocor – which are well known for their ability to significantly reduce cholesterol levels.

Can drinking water lower your creatinine levels?

Drinking more water could lower the serum creatinine level, but does not change kidney function. Forcing excessive water intake is not a good idea. I suggest that you drink based on thirst and not excessively hydrate.

Can statins cause kidney problems?

Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.

Is a 3.2 creatinine level bad?

Note that any creatinine level above 3.1 mg/dL should be considered overt kidney failure, because all values in the columns of eGFR that equal 15 in Table 1 are greater than 3.1. Also, note that even “normal” serum creatinine values may be considered renal insufficiency (eg, 0.9 mg/dL in a 90-year-old nonblack woman).

What causes low creatinine?

Low blood creatinine levels can mean lower muscle mass caused by a disease, such as muscular dystrophy, or by aging. Low levels can also mean some types of severe liver disease or a diet very low in protein. Pregnancy can also cause low blood creatinine levels.

How do you get low creatinine?

Here are 8 ways to naturally lower your creatinine levels.Don’t take supplements containing creatine. … Reduce your protein intake. … Eat more fiber. … Talk with your healthcare provider about how much fluid you should drink. … Lower your salt intake. … Avoid overusing NSAIDs. … Avoid smoking. … Limit your alcohol intake.

What medications are hard on kidneys?

Which Drugs are Harmful to Your Kidneys?Pain Medications. Your kidneys could be damaged if you take large amounts of over-the-counter medications, such as aspirin, naproxen and ibuprofen. … Alcohol. … Antibiotics. … Prescription Laxatives. … Contrast Dye (used in some diagnostic tests such as MRIs) … Illegal Drugs. … What should you do?

What level of creatinine requires dialysis?

When creatinine levels are high, it can be an indicator of kidney disease. For adults, dialysis is recommended when estimated glomerular filtration rate (GFR) levels reach approximately 10.0 ml/min.

What medications can cause low creatinine levels?

The antibiotic trimethoprim-sulfamethoxazole and the H2-blocker cimetidine are 2 commonly used drugs that decrease the secretion of creatinine. This can result in a self-limited and reversible increase in the serum creatinine level of as much as 0.4 to 0.5 mg/dL (depending on baseline serum creatinine level).

How do statins affect creatinine levels?

There is a risk with statins of rhabdomyolysis, or skeletal muscle injury, causing the increased creatinine level, the same as an acute kidney injury would.